Meglumine CAS#6284‑40‑8
Meglumine is a glucose‑based secondary amine widely used as a pharmaceutical excipient. It is available as pharmaceutical secondary standards for QC testing, providing labs and manufacturers a cost‑effective alternative to in‑house working standards.
Meglumine Chemical Properties |
Melting point | 129-131.5 °C (lit.) |
alpha | -16.5 º (c=10, H2O, on dry sub) |
Boiling point | 331.88°C (rough estimate) |
bulk density | 300kg/m3 |
density | 1.2669 (rough estimate) |
refractive index | -16.5 ° (C=2, H2O) |
RTECS | LZ4295770 |
storage temp. | 2-8°C |
solubility | H2O: 0.1 g/mL, clear, colorless |
pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
form | Crystalline Powder |
color | White to almost white |
PH | 11 (10g/l, H2O, 20℃) |
biological source | synthetic (organic) |
Optical Rotation | [α]20/D 16.5±0.5°, c = 2% in H2O |
Water Solubility | 100 g/100 mL (25 ºC) |
Sensitive | Air Sensitive & Hygroscopic |
Merck | 14,6078 |
BRN | 385906 |
Major Application | pharmaceutical (small molecule) |
Cosmetics Ingredients Functions | HAIR CONDITIONING |
InChI | 1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1 |
InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
SMILES | CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
LogP | -3.370 (est) |
NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
EPA Substance Registry System | Meglumine (6284-40-8) |
Safety Information |
Risk Statements | 36/37/38 |
Safety Statements | 24/25 |
WGK Germany | 3 |
F | 3-10-23 |
Autoignition Temperature | ~662 °F |
TSCA | TSCA listed |
HS Code | 29221980 |
Storage Class | 11 - Combustible Solids |
Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
Product Application Of Meglumine CAS#6284‑40‑8
Meglumine (N‑Methyl‑D‑glucamine) can form soluble salts with iodinated organic compounds for X‑ray contrast media such as diatrizoate meglumine and iodipamide meglumine. It acts as a selective boron‑chelating component in ion‑exchange resins. Besides being a pharmaceutical excipient for drug and cosmetic formulas, it is also utilized for synthesizing surfactants, pharmaceutical intermediates and dye substances.
Product Basic Information
Basic Identifiers
Product Name: Meglumine
Synonyms: N‑Methyl‑D‑glucamine, 1‑deoxy‑1‑(methylamino)‑d‑glucitol
CAS: 6284‑40‑8
MF: C₇H₁₇NO₅
MW: 195.21
EINECS: 228‑506‑9
Appearance: White crystalline powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Chemical & Physical Properties
Melting point: 128‑132 °C
Solubility: Highly soluble in water; slightly soluble in alcohol
PH (10 g/L water): 10.5‑11.0
Storage temp: Cool and dry place, tightly sealed
Stability: Stable under regular conditions; avoid aluminum and copper containers
Purity: Standard grade ≥99.0% (pharma grade complying with USP / Ph.Eur specifications)
Production Preparation Method
Meglumine is produced by condensation reaction between glucose and monomethylamine in alcoholic solvent, followed by catalytic hydrogenation. Crude material is purified by recrystallization, filtration and drying to obtain finished crystalline powder. Strict impurity control is implemented for pharmaceutical‑grade products.
Detailed Application Scenarios
Pharmaceutical & Medical Imaging
It serves as key excipient and counter‑ion for X‑ray contrast media. It improves water‑solubility of iodinated contrast agents, widely applied for diatrizoate meglumine and other diagnostic injectable formulations. It also works as pH regulator and solubilizer for various injectable and oral drug preparations.
Resin & Water Treatment
Applied in ion‑exchange resin systems for selective chelation and removal of boron ions from aqueous solutions.
Fine‑chemical Synthesis
Used as building block for manufacturing surfactants, pharmaceutical intermediates and dye compounds. It can also be supplied as pharmaceutical secondary standards for laboratory quality‑control testing.
Cosmetic Raw Material
Functions as pH‑adjusting additive in cosmetic formulations.
Upstream & Downstream Product Information
Upstream Raw Materials
Glucose, monomethylamine, alcohol solvent, hydrogen gas, hydrogenation catalyst.
Downstream Derivatives
Meglumine‑based contrast‑media salts, boron‑selective ion‑exchange resin, drug soluble‑salt intermediates, surfactant and dye precursors.
Safety & Handling Information
Low‑toxic organic amine powder. Dust may irritate respiratory tract and eyes.
Skin contact: Rinse skin with plenty of clean water.
Eye contact: Flush eyes with running water for several minutes; seek medical help if irritation persists.
Inhalation: Move to fresh‑air environment. Avoid dust inhalation, wear dust‑proof mask and goggles during operation.
Storage: Keep tightly sealed. Do not store in aluminum or copper containers; stainless‑steel or HDPE packaging is recommended.
Transport: Ordinary non‑hazardous chemical goods.
Packaging & Transportation
Available Packaging Options
Bulk industrial & pharma grade: 25 kg kraft paper bag with inner PE liner
Ton‑bag: 500‑1000 kg jumbo bag for full‑container shipment
Lab sample: 500 g /1 kg sealed HDPE plastic container. Custom packaging is available.
Delivery Cycle
Spot inventory order: 2‑3 working days
New customized production batch: 7‑10 working days
Full‑container sea shipment: Subject to container booking schedule.
Transport Requirement
General chemical cargo. Keep packages sealed and moisture‑proof. MSDS and batch‑by‑batch COA documents are provided for each shipment.
After‑sales Service Support
Document service: Free provision of batch COA, MSDS and relevant pharmaceutical specification documents.
Technical support: Our team offers formulation reference, dosage guidance and specification matching consultation within 24 working hours.
Quality complaint handling: Re‑delivery or exchange is available for confirmed quality defects. Customers should provide photos, videos and order information within 7 days upon receipt. Damage caused by improper storage is not covered, while technical guidance remains available.
Sample service: Test samples are available for lab pre‑evaluation before bulk purchase.
Customer Application Cases
Case 1: Pharmaceutical raw‑material manufacturer
A pharma enterprise purchases our USP‑grade meglumine for producing X‑ray contrast‑media intermediate salts. Strict impurity indexes meet injectable‑formula production requirements.
Case 2: Water‑treatment material factory
Our meglumine is adopted for boron‑selective ion‑exchange resin synthesis, delivering stable boron‑chelating performance for industrial water treatment.
Case 3: Pharmaceutical QC laboratory
Customers use our high‑purity meglumine as secondary reference standard for daily quality‑control testing of drug products.
FAQ Frequently Asked Questions
Q1: What is the difference between industrial grade and pharmaceutical grade meglumine?
A: Pharma grade complies with USP / Ph.Eur monographs, with strict control over heavy‑metal, reducing‑substance and ash content for drug formulation. Industrial grade is mainly for fine‑chemical synthesis and resin production.
Q2: Why cannot store meglumine in aluminum containers?
A: Meglumine is alkaline; it reacts with aluminum and generates hydrogen gas, leading to container corrosion and product discoloration. HDPE or stainless‑steel containers are recommended.
Q3: What is its shelf‑life?
A: 24 months under original sealed, cool and dry storage. Seal tightly after opening to prevent moisture absorption.
Q4: Can meglumine be directly used in injectable products?
A: Only qualified pharmaceutical‑grade meglumine can be applied. It must follow corresponding pharmacopoeia standards and complete formulation validation.
Factory & Equipment Show
Our workshop is equipped with hydrogenation reaction units, recrystallization systems, dust‑free drying and sealed filling facilities. Every batch undergoes melting‑point, purity and impurity testing before shipment to guarantee stable batch‑to‑batch quality.
Fast delivery time
Inventory 2‑3 working days New production 7‑10 working days
