Fluralaner, CAS#864731-61-3
Fluralaner (INN) belongs to the category of systemic insecticides and acaricides, and it is formulated for oral administration. This active ingredient is well known under the brand name Bravecto.
It obtained marketing approval from the European Union in February 2014. In May 2014, the U.S. Food and Drug Administration (FDA) granted its approval for flea treatment in dogs. Subsequently, Australia authorized this product in January 2015 for both the treatment and prevention of ticks and fleas infesting dogs.
Fluralaner Chemical Properties |
density | 1.51±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO:150.0(Max Conc. mg/mL);269.65(Max Conc. mM) |
form | A crystalline solid |
pka | 12.50±0.46(Predicted) |
color | White to off-white |
InChIKey | MLBZKOGAMRTSKP-UHFFFAOYSA-N |
SMILES | C(NCC(=O)NCC(F)(F)F)(=O)C1=CC=C(C2CC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)ON=2)C=C1C |
Fluralaner (CAS#864731‑61‑3)
Product Application Of Fluralaner CAS#864731‑61‑3
Fluralaner (CAS#864731‑61‑3) is a novel systemically‑acting insecticidal and acaricidal compound belonging to the isoxazoline chemical class. Delivered via oral administration to dogs, it achieves long‑lasting antiparasitic performance through systemic distribution throughout the animal’s organism.
Field study data confirms that a single oral dose of fluralaner delivers continuous flea and tick protection for a minimum of twelve weeks. Compared with conventional monthly flea‑and‑tick preventive treatments, its extended duration of action greatly simplifies treatment regimens, improves pet‑owner medication compliance, and effectively lowers the risk of vector‑borne infectious diseases transmitted by fleas and ticks.
Mechanistically, fluralaner antagonizes ligand‑gated chloride channels (GABA‑receptor and glutamate‑receptor) within arthropod nervous systems, disrupting nerve signal transmission and triggering parasite paralysis and death. It shows high biological selectivity for invertebrate parasites while exerting limited influence on mammalian nervous tissue. Beyond flea and tick control, this active ingredient demonstrates notable efficacy against mange mites including Sarcoptes and Demodex species in companion‑animal veterinary scenarios. It also suppresses flea egg‑laying and larval development to interrupt parasite reproduction cycles.
Main Application Scenarios
Veterinary API for Companion Animals
Serves as core raw material for oral chewable veterinary antiparasitic preparations for dogs; applicable for formulation development of flea‑tick‑mite control finished products.
Veterinary Formulation Research & Development
Supports laboratory formulation screening, stability testing and pre‑clinical trial material supply for veterinary pharmaceutical enterprises and research institutes.
Reference‑Standard Raw Material
Used as reference substance for impurity analysis and quality control in veterinary‑drug quality‑inspection laboratories.
Factory and Equipment Show
Our production base is equipped with dedicated production lines for veterinary‑grade active pharmaceutical ingredients, covering synthetic reaction units, crystallization, high‑precision drying and powder‑finishing processes. Strict closed‑loop manufacturing workflows are adopted to guarantee product purity, particle‑size consistency and stable batch‑to‑batch quality.
An independent QC laboratory is equipped with HPLC, GC and other sophisticated analytical instruments. Full‑item testing is implemented for incoming raw materials, reaction intermediates and finished‑product batches. Every shipment is released only after passing inspection, with corresponding COA documents provided for complete batch traceability.
Packaging & Transportation
Standard Packaging: 25 kg net weight per drum, packed in aluminium‑foil inner bag plus sealed fibre drum. Custom‑spec packaging (small trial‑order drums, custom‑printed shipping marks) can be arranged upon customer requirements.
Transport Classification: Classified as UN3077, Class 9 environmentally hazardous substance, packing group IIIMSD. Suitable for sea freight, air freight and land transport.
Storage Requirements: Keep sealed, store in cool and dry warehouse below 30 °C, avoid direct sunlight, high‑humidity environment and incompatible chemical reagents.
Shipping Documents: We provide full‑set customs‑clearance papers including commercial invoice, packing list, COA and MSDS.
Lead Time
In‑stock goods: Ready for shipment within 2‑3 working days upon receipt of payment
New production order: Production cycle 7‑10 working days, subject to order quantity and production scheduling.
We maintain safety stock for regular‑volume orders; priority production arrangement can be discussed for urgent projects.
After‑sales Service & Quality Commitment
Batch‑traceable Quality Guarantee: Each batch corresponds to complete test records and COA. If confirmed quality inconsistency occurs upon arrival, we will negotiate reasonable solutions such as product replenishment or compensation.
Professional Technical Support: Our technical team offers guidance covering storage conditions, material handling notes, formulation compatibility and common technical questions for veterinary‑drug R&D.
Document Support: Provide MSDS, COA, test reports and other certification files required for registration and customs clearance.
Order‑tracking Service: We keep updating logistics progress after shipment and respond to customer inquiries in a timely manner.
Reference Customer Cases
Cooperate with multiple veterinary‑pharmaceutical manufacturers for API bulk supply for chewable antiparasitic tablet R&D and commercial production.
Supply high‑purity trial‑batch material for veterinary‑drug research institutes for pre‑formulation and stability‑evaluation tests.
Provide reference‑standard‑grade samples for third‑party quality‑inspection laboratories for impurity profiling work.
FAQ
Q1: What purity grade of Fluralaner can you supply?
A: Our regular supply is ≥98% assay for veterinary‑API grade; custom‑grade specifications can be negotiated according to customer project requirements.
Q2: Can I get small‑quantity trial samples before bulk order?
A: Yes, sample supply is available for laboratory evaluation; please contact our sales team for sample specification and freight arrangement.
Q3: What are the key points for fluralaner raw‑material storage?
A: Keep containers tightly sealed; store under 30 °C in dry and dark warehouse. Avoid moisture and direct sunlight; do not mix and store with strong oxidants.
Q4: Does fluralaner produce cross‑resistance with other traditional parasiticides?
A: Fluralaner belongs to isoxazoline series; it generally shows no cross‑resistance against many conventional insecticide classes such as pyrethroids and macrocyclic lactonesMSD Animal....
Q5: What documents will you provide for import registration?
A: We can offer COA, MSDS, packing list, commercial invoice; additional supporting documents can be discussed as per local regulatory requirements.
