SOLASONINE CAS#19121‑58‑5
Solasonine is a natural steroidal glycoalkaloid widely distributed across multiple plant species belonging to the Solanum genus, including S. aviculare, S. sodomeum, S. verbascifolium and S. xanthocarpum.
This bio‑active alkaloid can be recrystallized from 80% ethanol to form hydrous crystals containing 4.5 molecules of water, displaying a melting point of 245‑250 °C with decomposition upon heating. Its anhydrous crystalline form can be obtained by recrystallization from absolute methanol. It presents a specific rotation value of [α]₂₅ᴰ ‑68° when dissolved in ethanol. Multiple derivative salts can be prepared from this compound: hydrochloride with melting point at 265 °C, picrate melting at 199‑201 °C, picrolonate melting at 230 °C, as well as its acetyl derivative with melting point ranging from 135‑138 °C. When subjected to alkaline hydrolysis conditions, the molecule breaks down to produce solasodine aglycone, alongside one‑mole equivalent each of galactose, glucose and rhamnose sugar units.
When mixed with concentrated sulfuric acid, its solution gradually develops a distinct crimson colour accompanied by brown fluorescence, which serves as a typical identification reaction for this substance. In terms of solubility performance, it dissolves readily in hot ethanol and hot dioxane, shows limited solubility in hot water and dilute acetic acid, while being practically insoluble in chloroform and diethyl ether.
Industrially, this compound is mainly extracted from the fruit of Solanum aviculare Forst., a well‑documented plant species within the Solanaceae family, and undergoes strict purification procedures to meet research and intermediate‑grade material requirements.
SOLASONINE Chemical Properties |
Melting point | 301-303℃ |
alpha | D23 -88° (c = 1.01 in pyridine); D22 -74.5° (c = 0.51 in methanol) |
density | 1.42 |
solubility | DMSO : 100 mg/mL (113.11 mM; Need ultrasonic) |
form | powder |
pka | 12.78±0.70(Predicted) |
color | White-beige |
InChIKey | QCTMYNGDIBTNSK-YQBIRKIONA-N |
LogP | 4.350 (est) |
SOLASONINE Chemical Properties
Solasonine features stable and standardized physicochemical properties. Its melting point is 301–303℃. The specific rotation is D23 -88° (c = 1.01 in pyridine) and D22 -74.5° (c = 0.51 in methanol), with a density of 1.42. The product shows good solubility in DMSO, reaching 100 mg/mL (113.11 mM) with ultrasonic assistance required for full dissolution. It appears as white-beige powder form. The predicted pKa value is 12.78±0.70, and the estimated LogP value is 4.350. Its fixed InChIKey is QCTMYNGDIBTNSK-YQBIRKIONA-N for accurate chemical identification.
Product Application of SOLASONINE CAS#19121-58-5
α-Solasonine is a pure natural glycoalkaloid compound derived from Solanaceae plants. It has prominent biological activity and is commonly applied in biomedical research. Relevant studies prove that it can effectively inhibit Gli-mediated transcriptional activity, serving as a key experimental material for pharmacological research and new drug development.
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