N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine | Ishikawa’s Reagent
CAS No.: 309-88-6
Molecular Formula: C₇H₁₁F₆N
Molecular Weight: 223.16
MDL Number: MFCD00054683
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine, widely known as Ishikawa’s Reagent, is a premium fluorinated amine fluorinating agent for fine chemical and pharmaceutical synthesis. It is a clear liquid designed for selective fluorination under mild reaction conditions, commonly used to convert alcohols into corresponding fluorides with good stereochemical inversion for chiral substrates.
This reagent demonstrates excellent chemoselectivity: it preferentially reacts with hydroxyl groups while remaining inert toward ketones and aldehydes, reducing side reactions and simplifying purification workflows. It serves as a core building block for manufacturing fluorine-containing APIs, veterinary antibiotics (e.g., Florfenicol), agrochemical intermediates, and specialty fluorinated materials with enhanced thermal stability and chemical resistance.
| N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Chemical Properties |
| Boiling point | 56-57 °C (lit.) |
| density | 1.230 g/mL at 25 °C (lit.) |
| refractive index | 1.3460 |
| Fp | 56-57°C/58mm |
| storage temp. | Flammables area |
| solubility | soluble in Acetone,Ether |
| pka | 1.50±0.70(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.230 |
| Merck | 14,5108 |
| InChI | 1S/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3 |
| InChIKey | BNTFCVMJHBNJAR-UHFFFAOYSA-N |
| SMILES | CCN(CC)C(F)(F)C(F)C(F)(F)F |
| CAS DataBase Reference | 309-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | N,N-Diethyl-2H-perfluoropropanamine (309-88-6) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 10-34 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | 3267 |
| WGK Germany | 3 |
| Hazard Note | Corrosive |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29211999 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Flam. Liq. 3 Skin Corr. 1B |
Key Physical Properties
Appearance: Clear colorless liquid
Boiling Point: 56–57 °C
Density: 1.230 g/mL at 25 °C
Refractive Index: n20/D 1.3460
Flash Point: 40 °C
Typical Applications
Selective fluorination of primary, secondary and chiral alcohols
Synthesis of fluorinated pharmaceutical intermediates and veterinary drugs
Friedel-Crafts type arylation for hydrofluorocarbons
R&D of advanced fluorine-containing fine chemicals and functional materials
Laboratory and pilot-scale custom organic synthesis
Our Advantages
Available in multiple purity grades (≥90%, ≥95%) and scalable packaging from lab grams to bulk MT quantities. We provide full supporting documents including COA, MSDS, and origin certificates to meet export and regulatory compliance requirements. Strict quality control ensures batch consistency for continuous industrial production and research projects.
Storage & Handling
Store sealed at 2–8 °C, protected from light and moisture. Keep away from heat, open flame and strong oxidizers. Operate under inert atmosphere with proper PPE following GHS safety guidelines.
