Poly(methylhydrosiloxane) serves as a versatile, mild polymeric reducing agent widely adopted in organic synthetic chemistry. It demonstrates reliable performance in a broad scope of reduction reactions. For instance, it enables the reduction of esters into corresponding alcohols, and effectively reduces aldehydes and ketones to their respective alcohol derivatives. Beyond carbonyl compounds, this silicon-based reducing agent can facilitate the transformation of phosphine oxides to phosphines under appropriate catalytic conditions. A growing number of recent research works further expand its application scope, employing poly(methylhydrosiloxane) for the conjugate reduction of α, β-unsaturated carbonyl compounds and carboxyl derivatives. Additionally, it acts as a practical reducing reagent for greener synthetic routes of amines via reductive amination reactions. This application provides a viable alternative to conventional borohydride reducing agents, helping to reduce harsh reaction conditions and improve environmental friendliness in synthetic workflows.
Poly(methylhydrosiloxane) Chemical Properties
Melting point
<-60°C
Boiling point
142 °C(lit.)
density
1.006 g/mL at 25 °C (lit.)
vapor pressure
38 hPa (20 °C)
refractive index
n20/D 1.382(lit.)
Fp
204 °C
storage temp.
Store below +30°C.
solubility
Soluble in most ethereal, chlorinated, or hydrocarbon solvents as well as EtOH, i-PrOH, warm DMF, and warm NMP; insoluble in MeOH, DMSO, acetonitrile, and water
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