DAURICINE CAS#524-17-4
Dauricine represents a naturally‑occurring plant‑derived metabolite, a bioactive bisbenzylisoquinoline alkaloid primarily extracted from the rhizome of Asiatic Moonseed as well as Canadian moonseed. This compound has long occupied an important position within traditional Chinese herbal applications, where it is widely applied for relieving multiple types of inflammatory‑related conditions. Its chemical total synthesis was first accomplished by Japanese research teams back in 1964, laying a solid foundation for subsequent global research and development of this natural alkaloid.
Accumulated pharmacological research findings have verified that Dauricine delivers a broad spectrum of bio‑functional effects within biological systems. One well‑documented property lies in its capacity to suppress the proliferation of malignant cancer cells; meanwhile, it is capable of interfering with cardiac transmembrane sodium, potassium and calcium ion channel activities, which is closely associated with its cardiovascular‑relevant pharmacological performancePMC. A growing body of contemporary pre‑clinical studies further uncovers promising new therapeutic potentials of Dauricine for cancer prevention and intervention. Substantial experimental evidence demonstrates its notable anti‑tumor activity across multiple malignant tumor models. The covered cancer types include colorectal cancer, breast cancer, together with urinary system malignancies such as bladder cancer and prostate cancer, attracting continuous interest from pharmaceutical and natural‑product research communities worldwide.
DAURICINE Chemical Properties |
Melting point | 115° |
alpha | D11 -139° in methanol |
Boiling point | 712.3±60.0 °C(Predicted) |
density | 1.185±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 9.31±0.45(Predicted) |
form | Solid |
color | Pale Beige |
Water Solubility | slightly soluble in water |
InChIKey | AQASRZOCERRGBL-ROJLCIKYSA-N |
SMILES | C1(O)=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1 |
CAS DataBase Reference | 524-17-4 |
Dauricine belongs to the bisbenzylisoquinoline class of alkaloid compounds and possesses a broad array of valuable pharmaceutical‑related properties, rendering it a sought‑after raw material for pharmaceutical research, pre‑clinical study and natural‑product development. As a biologically active plant‑sourced molecule, it draws extensive focus from research institutions and R&D teams for its multiple pharmacological effects. It should be noted that relevant animal experiments have confirmed that this substance can trigger obvious lung toxicity in animal subjects under certain dosage conditions, which serves as an important toxicological reference for laboratory research, risk assessment and formulation design during drug‑related development work.
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