Arbutin is a glycoside naturally present in Arctostaphylos plants. It possesses multiple biological activities including tyrosinase‑inhibiting, antioxidant and anti‑inflammatory effects.
It can suppress human tyrosinase activity both in crude enzyme solution extracted from human melanocytes (IC₅₀ = 5.7 mM for L‑tyrosine substrate; IC₅₀ = 18.9 mM for L‑DOPA substrate) and in intact melanocytes (IC₅₀ = 0.5 mM). At 50 μM, arbutin inhibits AAPH‑triggered hemolysis in sheep red blood cells. Concentrations above 125 μM can counteract AAPH‑caused viability reduction in cultured human skin fibroblasts.
In the LPS‑induced acute lung injury rat model, 50 mg/kg arbutin treatment reduces the elevation of IL‑1β, IL‑6 and TNF‑α in lung tissue and serum. Formulations added with arbutin are applied to improve hyperpigmentation‑related skin conditions.
Parameters
Melting point | 195-198 °C |
alpha | -64 º (c=3) |
Boiling point | 375.31°C (rough estimate) |
density | 1.3582 (rough estimate) |
refractive index | -65.5 ° (C=4, H2O) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | H2O: 50 mg/mL hot, clear |
form | Solid |
pka | 10.10±0.15(Predicted) |
color | White |
optical activity | [α]/D -64.0±2.0°, c = 3 in H2O |
biological source | synthetic or plant |
Water Solubility | 10-15 g/100 mL at 20 ºC |
Sensitive | Hygroscopic |
Merck | 14,773 |
BRN | 89673 |
Stability: | Stable. Hygroscopic - store under dry nitrogen. |
InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
LogP | -1.350 |
CAS DataBase Reference | 497-76-7(CAS DataBase Reference) |
EPA Substance Registry System | .beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7) |
Safety Information
Hazard Codes | Xn |
Risk Statements | 20/21/22-36/37/38 |
Safety Statements | 22-24/25-36-26 |
WGK Germany | 3 |
RTECS | CE8863000 |
F | 3-10-23 |
HS Code | 29389090 |
Hazardous Substances Data | 497-76-7(Hazardous Substances Data) |
Product Application of Arbutin CAS#497‑76‑7
<h2>Product Overview</h2>
Arbutin (CAS#497‑76‑7), also known as 4‑Hydroxyphenyl β‑D‑Glucopyranoside, is a glycoside compound. It shows tyrosinase‑inhibitory, antioxidant and anti‑inflammatory bio‑activities. The substance can be applied in urinary‑system diuretic & anti‑infective pharmaceuticals, color‑photography developing stabilizers, as well as whitening, anti‑freckle and hair‑care cosmetic raw materials.
<h2>Application Scenarios</h2>
<h3>Pharmaceutical Field</h3>
Used as raw material for diuretic and anti‑infective medicines targeting the urinary system. It exerts bacteriostatic and anti‑inflammatory effects to assist in relieving related urinary‑tract discomforts. It can also serve as reference substance and intermediate for pharmaceutical laboratory analysis and formula research.
<h3>Cosmetic Industry</h3>
As classic whitening and brightening active ingredient, it is widely added into serums, facial creams, spot‑fading essences, masks and hair‑care formulas. By inhibiting tyrosinase activity, it reduces melanin generation, improves freckles, sun spots and uneven skin tone. It features mild performance and fits for sensitive‑skin cosmetic development.
<h3>Photographic & Special Chemical Industry</h3>
Functions as developing stabilizer for color photographic processing, stabilizing solution system and improving image quality during developing procedures. It can also be adopted as biochemical reagent for laboratory melanin‑related mechanism research.
<h2>Packaging & Transportation</h2>
<h3>Standard Packaging</h3>
Small test order: 1 kg / 5 kg aluminum‑foil bag with inner PE liner, moisture‑proof and light‑shielding. Bulk export: 25 kg fiber drum with double inner plastic bags. Each batch is marked with product name, CAS number, batch No., net weight and production & expiry date. Custom‑tailored packing specifications are acceptable upon client request.
<h3>Transport Requirements</h3>
Transport under cool and dry conditions, keep away from strong sunlight, high‑temperature heat sources and humid environment. Avoid mixing shipment with strong‑oxidizing and strongly‑alkaline goods. It is non‑hazardous general chemical goods for international logistics; sea freight, air freight and express delivery are all optional.
<h2>Storage Guidance</h2>
Store in tightly‑sealed containers, cool‑dry dark warehouse, recommended storage temperature ≤25 °C. Prevent moisture absorption and light degradation. Unopened original package shelf‑life reaches 24 months. Once opened, finish consumption within 6 months.
<h2>Quality Assurance & After‑sales Service</h2>
<h3>Batch‑wise Quality Control</h3>
Every lot completes internal HPLC, heavy‑metal and impurity detection before delivery. Supporting documents including COA, TDS, MSDS can be supplied for customs clearance and product registration. Third‑party inspection can be arranged if required.
<h3>After‑sales Support</h3>
Offer technical suggestions for formulation compatibility, recommended adding‑dosage and applicable pH range. If any quality or quantity discrepancy occurs upon receiving goods, please provide batch‑related evidence; our team will respond and propose solutions quickly. Long‑term framework supply service is available for stable bulk purchasers.
<h2>Typical Customer Cases</h2>
Cosmetic raw‑material distributors from Southeast Asia: Purchase cosmetic‑grade arbutin in bulk for local whitening serum and mask production, stable repeated orders for over 2 years.
Biochemical‑research laboratories in Europe: Place small‑batch trial purchases as lab reagent for melanin‑inhibition mechanism study.
Fine‑chemical manufacturers: Adopt this product as photographic‑developing stabilizer intermediate for special chemical formula research.
<h2>FAQ</h2>
<h3>Q1: What is the recommended adding‑amount in cosmetic formulas?</h3>
A: Common addition ratio ranges 1%‑5%. Formulation pH better keeps between 4.0‑7.0; avoid long‑time high‑temperature heating and strong‑alkaline environment to prevent performance degradation.
<h3>Q2: Can you provide sample for testing?</h3>
A: Yes, small‑quantity test samples are available for client formulation verification before bulk order placement.
<h3>Q3: What is your production & delivery cycle?</h3>
A: In‑stock goods can be delivered within 2‑3 working days. For out‑of‑stock mass production, lead‑time is 7‑10 working days.
<h3>Q4: Which payment terms are supported for overseas orders?</h3>
A: We accept T/T, L/C and other international settlement methods; terms can be negotiated for long‑term cooperative clients.
<h2>Factory and Equipment Show</h2>
Modern fine‑chemical production workshop, complete raw‑material feeding, synthesis, purification and packaging equipment. Independent QC laboratory equipped with HPLC and related analytical instruments to realize full‑process monitoring from raw‑material input to finished‑product output.
