Products Description of Chlorogenic acid, CAS#327-97-9
Chlorogenic acid is a bioactive polyphenol widely present in various plants, with coffee being a typical source. It has significant neuroprotective effects, as well as antiviral, antifungal, antioxidant and anti-tumor activities. Besides, chlorogenic acid (CGA) can help regulate glucose and lipid metabolism and improve insulin sensitivity.
Parameters
Melting point | 210 °C (dec.) (lit.) |
alpha | -36 º (c=1, H2O) |
Boiling point | 407.55°C (rough estimate) |
density | 1.3594 (rough estimate) |
refractive index | -37 ° (C=1, H2O) |
storage temp. | 2-8°C |
solubility | Soluble in ethanol and acetone. |
pka | 3.91±0.50(Predicted) |
form | Powder, Crystals, Needles and/or Chunks |
color | White to almost white |
Water Solubility | SOLUBLE IN HOT WATER |
Merck | 14,2142 |
InChIKey | CWVRJTMFETXNAD-JUHZACGLSA-N |
LogP | -0.356 (est) |
CAS DataBase Reference | 327-97-9(CAS DataBase Reference) |
EPA Substance Registry System | Chlorogenic acid (327-97-9) |
Safety Information
Hazard Codes | Xi |
Risk Statements | 68 |
Safety Statements | 24/25 |
WGK Germany | 3 |
RTECS | GU8480000 |
Hazard Note | Irritant |
HS Code | 29182900 |
Toxicity | LDLo intraperitoneal in rat: 4gm/kg |
Product Application of Chlorogenic acid CAS#327‑97‑9
Chlorogenic acid is a natural polyphenolic active substance extracted from medicinal plants. It has broad antibacterial effect, cholagogic, hemostatic, leukocyte‑increasing and antiviral effect, and can shorten blood‑clotting and bleeding time. It is applied for upper respiratory tract infection treatment, anti‑inflammatory and antipyretic effect, cooling blood and removing heat. It serves as key raw material and intermediate for pharmaceutical manufacturing, clearing heat and removing toxicity, relieving wind‑heat cold symptoms. It delivers broad‑spectrum antimicrobial properties and shows obvious inhibitory effect against hemolytic streptococcus, dysentery bacillus and salmonella typhi。
<h2>Core Biological Functions</h2>
<h3>Antimicrobial & Antiviral Activity</h3>
Chlorogenic acid exerts broad‑spectrum inhibition toward multiple gram‑positive and gram‑negative bacteria, including hemolytic streptococcus, dysentery bacillus and salmonella typhi. It suppresses viral replication through interfering with virus adsorption and invasion process. Different from synthetic bactericides, it hardly induces drug‑resistant strains under conventional dosage.
<h3>Anti‑inflammatory, Antipyretic & Hemostatic Properties</h3>
It relieves inflammatory response by regulating inflammatory cytokine release. It supports antipyretic effect for wind‑heat related symptoms, accelerates blood coagulation process and shortens bleeding time, meanwhile promotes leukocyte regeneration to enhance local immune defense. It also provides cholagogic effect to stimulate bile secretion and protect hepatobiliary function.
<h3>Powerful Antioxidant & Metabolic‑Regulating Activity</h3>
As a typical polyphenol ingredient, it effectively scavenges free radicals, alleviates oxidative cell damage. It inhibits carbohydrate‑decomposing enzymes to slow post‑meal glucose absorption; it also helps regulate lipid metabolism and support cardiovascular protection.
<h2>Application Scenarios</h2>
<h3>Pharmaceutical Raw Material & Intermediates</h3>
Used for manufacturing preparations targeting upper respiratory tract infection, heat‑clearing anti‑inflammatory formulations, hemostatic compound preparations. It works as synthetic intermediate for anti‑infective botanical drugs, suitable for oral solid preparations and liquid formula production under GMP standard. It can be applied for compound prescriptions for heat‑toxin removal and wind‑heat cold relief.
<h3>Dietary Supplement & Functional Food Field</h3>
Added into capsules, tablets, granular sachets and functional beverages. Main development directions include immune‑support formula, antioxidant formula, carbohydrate‑metabolism regulating products. It can be incorporated into baked goods, functional drinks as clean‑label plant‑derived antioxidant additiveNanjing Nu....
<h3>Cosmetic & Personal‑care Raw Material</h3>
Applied in anti‑aging serums, soothing toner and repair cream. Its free‑radical‑scavenging capacity reduces skin oxidative damage caused by UV exposure; its mild anti‑inflammatory property helps soothe irritated skin. It also delivers certain tyrosinase‑inhibiting performance for brightening‑related formula development. Note that chlorogenic acid is sensitive to light and oxidation, micro‑encapsulation is recommended to improve formulation stabilityPMC.
<h3>Animal Nutrition & Feed Additive</h3>
Used as plant‑source feed additive for livestock and poultry. It improves animal antioxidant status, reduces stress response, inhibits harmful intestinal bacteria and decreases usage of synthetic antimicrobial additives in animal feeding formulas.
<h2>Product Specification Reference</h2>
CAS No: 327‑97‑9
Appearance: Off‑white to white fine crystal powder
Assay: 5%‑98% (tested by HPLC)
Solubility: Freely soluble in water and polar solvent
Source: Eucommia leaf / Honeysuckle / Green coffee bean extract
Shelf life: 24 months under proper storage conditionAlibaba.co...
<h2>Packing & Transportation</h2>
<h3>Packing Options</h3>
Small trial‑order package: 1kg‑5kg, sealed aluminum‑foil vacuum bag, inner with moisture‑proof desiccant.
Bulk commercial package: 25kg net weight per fiber drum; inner double PE plastic bag for sealing.
Customized package service is available for large‑batch orders (custom label and packing requirement negotiable for MOQ≥100kg).
<h3>Storage & Transit Requirements</h3>
Keep container tightly sealed; store in cool, dry and dark warehouse; avoid direct sunlight, high temperature and humid environment.
Avoid mixing shipment with strong oxidizing agents, strong acid and alkali goods.
For sea / air / express delivery: Sample goods (<50kg) can be delivered by international courier; bulk goods support sea freight or air freight from China main ports.
Transit time: 2‑4 working days for sample dispatch; 7‑15 working days for bulk goods upon receiving deposit.
Important reminder: Chlorogenic acid is air‑sensitive, oxidation may cause color deepening once exposed to air for long‑time; please keep sealed after opening the packageTokyo Chem....
<h2>After‑sales Service</h2>
<h3>Document Support</h3>
We provide full set of trade documents including COA, HPLC test report, TDS, SDS, packing list, commercial invoice, bill of lading. For special market, we support providing related certification auxiliary materials upon customer demand.
<h3>Quality Feedback Handling</h3>
If customers receive goods with quality discrepancy against COA, please provide photos, video and third‑party inspection report within 15 working days after goods arrival. Our QA team will review evidence rapidly and offer solutions including re‑delivery, partial compensation or price negotiation according to actual situation.
<h3>Technical Support</h3>
Our technical team offers basic formulation reference, storage guidance and common‑problem consultation for your R&D team. We do not provide final‑product production formula for commercial finished goods.
<h2>Typical Customer Cases</h2>
<h3>Case 1: European dietary‑supplement manufacturer</h3>
Customer purchases 98‑purity chlorogenic acid (Eucommia‑leaf source) monthly for capsule production for metabolic‑health supplement. Customer adopts micro‑encapsulation processing to improve raw‑material stability. Long‑term monthly order volume ranges from 80kg‑150kg.
<h3>Case 2: Domestic pharmaceutical intermediate factory</h3>
Customer orders medium‑purity chlorogenic acid as botanical raw material for compound anti‑inflammatory preparation. Goods are inspected by third‑party lab before shipment; stable quarterly bulk drum‑packing supply is maintained.
<h3>Case3: Korean cosmetic raw‑material importer</h3>
Small‑batch trial order for cosmetic‑grade chlorogenic acid, for anti‑oxidation soothing‑serum R&D. Customer conducts compatibility and stability testing before formal bulk procurement.
<h2>FAQ</h2>
Q1: Can I get free samples?
A1: Yes, 10‑50g trial samples are available. Customer bears international courier freight. Sample lead‑time is 2‑3 working days.
Q2: What is your MOQ?
A2: Trial‑order MOQ: 1kg; formal bulk‑order standard MOQ:25kg. We accept flexible small‑batch trial order for new‑product R&D purpose.
Q3: What payment terms do you accept?
A3: T/T in advance is primary term. L/C is negotiable for large‑volume long‑term contract orders.
Q4: How to avoid chlorogenic acid discoloration during storage?
A4: Keep package fully sealed, store below 25℃, away from light and moisture. Do not expose powder under open air for long time. Once drum is opened, finish usage within short period or transfer into vacuum‑sealed container.
Q5: What certificate can you provide?
A5: We can supply ISO‑related audit documents, COA, SDS, TDS. Kosher / Halal documents can be provided for qualified batch. Special region registration documents need further communication.
Q6: What is your production lead‑time?
A6: For regular‑spec in‑stock goods: arrange shipment within 3‑7 working days after deposit confirmation. For out‑of‑stock customized‑spec products, lead‑time is 10‑20 working days based on order quantity.
<h2>Quality Control Standard</h2>
Every batch undergoes in‑house QA detection (HPLC for assay, loss on drying, heavy‑metal, microbial limit test). Third‑party independent inspection is acceptable before shipment upon buyer’s request. Each delivery comes with corresponding batch‑specific COA report.
