Clotrimazole CAS#23593-75-1
Clotrimazole is a high-efficiency, broad-spectrum imidazole-class antifungal compound widely applied in pharmaceutical raw materials, medical formulations, and biochemical research fields. It exhibits powerful inhibitory and fungicidal activity against an extensive range of pathogenic fungi, including dermatophytes, yeasts, molds, and other fungal strains that commonly cause superficial and systemic fungal infections in humans and animals.
As a core mechanism of action, Clotrimazole specifically targets and tightly binds to sterol 14-α demethylase isoform B derived fromAspergillus fumigatus, with a high binding affinity recorded at KD = 103 nM. By blocking the activity of this key enzyme, the compound effectively suppresses ergosterol biosynthesis, an indispensable structural component of fungal cell membranes. This interference disrupts membrane fluidity, permeability, and integrity, leading to the leakage of intracellular substances, inhibition of fungal proliferation, and eventual fungal cell death. Consistent with the pharmacological characteristics of other imidazole antifungals, Clotrimazole delivers stable and reliable antifungal performance across multiple fungal species.
In addition to its prominent antifungal properties, Clotrimazole shows significant regulatory effects on mammalian ion channels. It potently inhibits two critical calcium-dependent potassium channels in mammalian cells, Kv1.3 and IK-1, with precise inhibitory concentrations of IC50 = 6.0 μM and IC50 = 0.07 μM respectively. This unique pharmacological feature also makes it an important research compound for cell physiology, immunology, and related biomedical studies.
Our Clotrimazole product appears as uniform white powder with high purity, stable chemical properties, low impurity content, and excellent batch consistency. Strictly produced and tested in accordance with international pharmaceutical standards, it is fully qualified for formulation processing, pharmaceutical manufacturing, laboratory research, and bulk global export. Complete technical documents including COA, MSDS, and full specification reports can be provided to support customer registration, tender submission, and import customs clearance.
| Clotrimazole Chemical Properties |
| Melting point | 147-149°C |
| Boiling point | 501.14°C (rough estimate) |
| density | 1.1095 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in chloroform, DMSO, DMF and alcohols |
| pka | pKa 4.7(EtOH 50%aq ) (Uncertain) |
| form | Solid |
| color | White to Almost white |
| Water Solubility | <10mg/L(25 ºC) |
| λmax | 556nm(Phosphate buffer sol.)(lit.) |
| Merck | 14,2417 |
| Major Application | pharmaceutical pharmaceutical small molecule |
| Cosmetics Ingredients Functions | ANTIMICROBIAL ANTI-SEBORRHEIC |
| InChI | InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H |
| InChIKey | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| SMILES | C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1 |
| NIST Chemistry Reference | Clotrimazole(23593-75-1) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | NI4377000 |
| HS Code | 29332900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Irrit. 2 |
| Hazardous Substances Data | 23593-75-1(Hazardous Substances Data) |
| Toxicity | LD50 in male mice, rats (mg/kg): 923, 708 orally (Tettenborn) |
