Sodium Dihydrogen Citrate, also widely known as Monosodium Citrate (CAS #: 18996-35-5), is a high-purity monobasic acid salt derived from citric acid, with the chemical formula NaH₂C₆H₅O₇ (C₆H₇NaO₇). As one of three core citrate salt series, it features unique acidic buffering performance and powerful chelating capacity, making it a versatile functional additive for food, pharmaceutical, diagnostic, and industrial applications.
Distinct from disodium citrate and trisodium citrate, monosodium citrate retains two active hydrogen groups on the citrate anion structure. This special molecular composition endows the product with strong sequestrant and metal ion chelating properties. It can effectively bind calcium, magnesium, and other metal ions in solutions, stabilize system pH value, inhibit metal ion oxidation and precipitation, and maintain long-term system stability in liquid formulations.
One of its most classic and critical applications is serving as a professional anticoagulant for clinical blood sample testing. Blood coagulation relies on calcium ions as an essential coagulation factor. By efficiently chelating free calcium ions in blood plasma, sodium dihydrogen citrate blocks the platelet aggregation and blood clotting cascade, effectively preventing blood sample coagulation during in vitro transportation, testing and storage. It ensures the accuracy of hematology analysis, biochemical detection and various clinical diagnostic experiments, which makes it a standard reagent in medical inspection laboratories worldwide.
Beyond medical and diagnostic usage, this product acts as an excellent pH buffer, acidity regulator, flavor modifier, and stabilizer in the food and beverage industry. It delivers mild and stable tartness, optimizes flavor balance, improves product texture, and extends shelf life by restraining microbial activity and ingredient deterioration. In industrial fields, it serves as an eco-friendly sequestering agent, cleaning auxiliary agent and reaction stabilizer, widely applied in metal surface treatment, electrochemical material synthesis and fine chemical formulation.
Our supplied Sodium Dihydrogen Citrate (CAS 18996-35-5) appears as a white, odorless crystalline powder, features high water solubility, stable chemical properties, low toxicity and good biodegradability. With strict quality control on purity, moisture and heavy metal content, it meets food-grade and pharmaceutical-grade application standards, supporting customized specifications for different industrial and laboratory scenarios.
Core Key Features
High-efficiency metal sequestrant and pH buffering agent
Professional blood anticoagulant for clinical laboratory testing
Stable acidic adjustment, no abrupt flavor or pH fluctuation
Food & pharmaceutical grade available, safe and biodegradable
Fine crystal powder, good solubility, easy formulation
Main Applications
Medical & Diagnostics: In vitro blood sample anticoagulant, clinical biochemical testing buffer, laboratory reagent
Food & Beverage: Acidity regulator, flavor enhancer, antioxidant stabilizer, shelf-life extender
Fine Chemicals: Metal ion chelating agent, industrial cleaning additive, reaction stabilizer
Biotechnology: Buffer solution preparation, biological sample preservation, reagent formulation
| SODIUM DIHYDROGEN CITRATE Chemical Properties |
| Melting point | 212 °C(lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 0.25 M at 20 °C, clear, colorless |
| form | Crystalline Powder |
| color | White |
| Odor | Odorless |
| PH | 4.07(1 mM solution);3.87(10 mM solution);3.71(100 mM solution);3.48(1000 mM solution) |
| Water Solubility | Soluble in water. Insoluble in ethanol. |
| λmax | λ: 260 nm Amax: 0.15 λ: 280 nm Amax: 0.05 |
| BRN | 3920246 |
| Cosmetics Ingredients Functions | BUFFERING |
| Cosmetic Ingredient Review (CIR) | SODIUM DIHYDROGEN CITRATE (18996-35-5) |
| InChI | InChI=1S/C6H8O7.Na.H/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);; |
| InChIKey | JKYDHHIKDADVTE-UHFFFAOYSA-N |
| SMILES | C(O)(C(=O)O)(CC(=O)O)CC(=O)O.[NaH] |
| CAS DataBase Reference | 18996-35-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monosodium salt (18996-35-5) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 22-24/25 |
| WGK Germany | 1 |
| RTECS | GE7950000 |
| F | 3 |
| TSCA | TSCA listed |
| HS Code | 29181500 |
| Storage Class | 11 - Combustible Solids |
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