Product Profile (Detail Page Version)
Tetrabutylammonium fluoride trihydrate (TBAF·3H₂O) is a high-purity quaternary ammonium fluoride salt widely adopted in organic synthetic chemistry, nucleic acid research and biochemical laboratory fields. Featuring strong fluorine ion activity and excellent solubility in organic solvents, it acts as a versatile deprotection reagent and strong organic base, standing as an indispensable core raw material for fine chemical synthesis and molecular biology experiments.
Physical Characteristic Advantages
This product is supplied as uniform, fine white powder with consistent particle size and outstanding anti-caking performance. The trihydrate crystal structure delivers stable fluoride ion activity, without excessive moisture fluctuation during storage and transportation. It dissolves rapidly in common polar organic solvents, bringing convenient operation for lab and industrial synthesis processes.
| Tetrabutylammonium fluoride trihydrate Chemical Properties |
| Melting point | 62-63 °C(lit.) |
| Fp | -17℃ |
| storage temp. | Store below +30°C. |
| form | Crystalline Powder, Crystals and/or Chunks |
| Specific Gravity | 0.887 |
| color | White to slightly yellow |
| PH | pH (50g/l, 25℃) : 5.0～8.0 |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 3761900 |
| Exposure limits | ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3 |
| InChI | InChI=1S/C16H36N.FH.H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;;/h5-16H2,1-4H3;1H;1H2/q+1;;/p-1 |
| InChIKey | UQCWXKSHRQJGPH-UHFFFAOYSA-M |
| SMILES | [N+](CCCC)(CCCC)(CCCC)CCCC.[F-].O |
| CAS DataBase Reference | 87749-50-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | C,Xi |
| Risk Statements | 34-36/37/38 |
| Safety Statements | 26-36/37/39-45-26 37/39 |
| RIDADR | UN 1759 8/PG 1 |
| WGK Germany | 3 |
| F | 3-10 |
| Hazard Note | Irritant |
| TSCA | T |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 38220000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Eye Irrit. 2 Repr. 2 Skin Irrit. 2 |
Core Product Performance & Application Merits
High-efficiency desilylation reagent
As a classic organic soluble fluoride source, TBAF trihydrate is widely adopted to remove silyl protecting groups in fine chemical, pharmaceutical and intermediate synthesis. It shows mild reaction condition and high conversion rate without introducing heavy metal impurities.
Widely used organic synthesis catalyst
It serves as a versatile phase transfer catalyst for fluorination, condensation and cross-coupling reactions, greatly improving reaction efficiency and product yield in organic synthesis workshops.
Strict controlled purity standard
The product reaches 97% minimum assay with low impurity content. Every batch is attached with complete COA test report to guarantee stable reaction performance and avoid side reactions in high-precision chemical synthesis.
Broad industrial application range
Perfect for pharmaceutical intermediates, electronic chemical synthesis, polymer modification, agrochemical research and fine organic lab synthesis, which meets diversified production demands from global chemical manufacturers.
