Gomisin A (CAS#58546‑54‑6)
Also known as Schisandrol B, this bioactive lignan monomer is purified from Schisandra chinensis, well‑recognized for its prominent hepatoprotective properties. It exerts biological effects mainly by modulating the pregnane X receptor (PXR), a vital regulator responsible for bile acid homeostasis.
This compound can markedly boost the expression levels of multiple PXR‑downstream target genes associated with bile acid metabolism. In mouse liver tissue, it up‑regulates Cyp3a11, Ugt1a1, Oatp2 and Mrp3; meanwhile, in HEK293T cell lines, it elevates the expression of human CYP3A4, UGT1A1 and OATP2, thereby optimizing hepatic bile acid clearance and detoxification function.
Pharmacological studies have demonstrated its protective effect against liver injury triggered by lithocholic acid. It is capable of alleviating lithocholic‑acid‑provoked hepatic necrosis as well as intrahepatic cholestasis in wild‑type mice, whereas such protective effects disappear in Pxr‑deficient mouse models. When dosed at 100 mg/kg twice daily, it can effectively reduce mortality rates in cholestatic‑disease mouse models. Beyond anti‑cholestasis benefits, Gomisin A also facilitates liver tissue repair and regeneration after partial hepatectomy surgery.
Furthermore, it delivers noticeable defensive action against acetaminophen‑elicited hepatotoxicity, showing multi‑faceted protective potential for liver function under different types of hepatic damage.
Gomisin A Chemical Properties |
Melting point | 88.5°C |
Boiling point | 454.79°C (rough estimate) |
density | 1.1772 (rough estimate) |
refractive index | 1.5300 (estimate) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
form | powder to crystal |
pka | 14.58±0.40(Predicted) |
color | White to Light yellow |
biological source | Schisandra chinensis |
InChI | 1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1 |
InChIKey | ZWRRJEICIPUPHZ-MYODQAERSA-N |
SMILES | C[C@]1([H])[C@@](C)(O)CC2=C(C(OC)=C(OC)C(OC)=C2)C3=C(OC)C4=C(OCO4)C=C3C1 |
LogP | 4.770 (est) |
Safety Information |
Safety Statements | 24/25 |
WGK Germany | WGK 3 |
HS Code | 29329990 |
Storage Class | 11 - Combustible Solidsb |
Product Application of Gomisin A, CAS#58546‑54‑6
Also known as Schisandrol B, this naturally‑occurring lignan displays remarkable protective bioactivity against cell injury induced by endothelin‑1 (ET‑1). It is capable of effectively alleviating functional abnormalities of human‑induced pluripotent stem cell‑derived cardiomyocytes (hiPS‑CMs), rendering it a highly useful research candidate for cardiovascular mechanism investigation and pharmacological compound screening work. Apart from its valuable cardioprotective characteristics, this compound also delivers distinct anti‑cholestasis effects, which provides solid experimental support for research projects targeting cholestatic liver damage and bile‑metabolism‑associated pharmacological studies.
In terms of delivery solutions, fast shipment service is offered to meet customers’ urgent‑order demands. In‑stock goods can be ready for dispatch within 2‑3 working days after order confirmation. For orders that need new batch production, the whole manufacturing period will take about 7‑10 working days prior to shipment.
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