Ibuprofen, with the chemical name 2-(4-isobutylphenyl)propanoic acid, is a classic non-steroidal anti-inflammatory drug (NSAID). It delivers outstanding triple efficacy: anti-inflammation, analgesia and antipyretic effects, paired with mild adverse reaction profiles, earning widespread recognition across global markets. Together with aspirin and paracetamol, it forms the trio of core antipyretic-analgesic raw materials and ranks among the best-selling OTC pharmaceutical ingredients globally.
Domestically in China, ibuprofen is mainly indicated for pain relief and rheumatic disorder therapy. Its clinical application for cold symptom relief and fever reduction is less prevalent, falling far behind aspirin and paracetamol in this specific scenario.
As a benchmark NSAID active pharmaceutical ingredient, ibuprofen works by inhibiting prostaglandin synthesis to block inflammatory reactions, relieve moderate to mild pain and suppress elevated body temperature. Its superior gastrointestinal tolerance compared to many other anti-inflammatory agents makes it ideal for long-term administration targeting chronic rheumatic pain, joint swelling and soft tissue injuries.
Globally, its formulations cover tablets, suspensions, capsules and topical creams, catering to diverse consumer groups including adults, children and the elderly. While fever and cold relief dominate its overseas consumer demand, Chinese manufacturers mostly deploy ibuprofen in prescription medicines for orthopedic and rheumatology departments. For household fever care, local consumers still prefer paracetamol due to long-standing clinical usage habits, creating differentiated market positioning for ibuprofen in domestic pharmaceutical distribution chains.
| Melting point | 77-78 °C |
| Boiling point | 157 °C (4 mmHg) |
| alpha | [α]D20 -1～+1°(c=1,C2H5OH) |
| density | 1.0364 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone, in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates. |
| pka | pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate) |
| form | Crystalline Powder |
| color | white to off-white |
| biological source | synthetic (organic) |
| Water Solubility | insoluble |
| Merck | 144881 |
| BCS Class | 2 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | HEFNNWSXXWATRW-UHFFFAOYSA-N |
| LogP | 3.97 |
| CAS DataBase Reference | 15687-27-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Ibuprofen(15687-27-1) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)- (15687-27-1) |
| Safety Information | |
| Hazard Codes | Xn |
| Risk Statements | 22-63-51/53-39/23/24/25-23/24/25-11 |
| Safety Statements | 36-61-36/37-45-16-7 |
| HS Code | 29163920 |
| Hazardous Substances Data | 15687-27-1(Hazardous Substances Data) |
| Toxicity | LD50 in male mice, rats (mg/kg): 495, 626 i.p.; 1255, 1050 orally (Orzalesi) |
Transportation & Packaging Information
Ibuprofen API is packed in standard food-grade pharmaceutical fiber drums lined with double PE plastic bags to isolate moisture, dust and external contamination. Each drum is sealed tightly with secure metal hoops to prevent leakage during long-distance transit.
This product belongs to general non-hazardous goods without dangerous goods classification, which greatly simplifies sea, air, land and rail logistics procedures. It can be shipped via regular general cargo containers without special dangerous goods declaration, cold chain transport or dedicated dangerous goods carriers.
During transportation, please store away from direct sunlight, high temperature and humid environment. Avoid heavy squeezing, violent collision and mixing with strong oxidants, acid and alkaline chemicals. We adopt reinforced pallet packaging for bulk orders to reduce damage risks in cross-border transportation. The outer carton/drum surface is clearly labeled with product name, specification, net weight, production batch and moisture-proof warning marks for easy customs inspection and cargo tracking.
