Tussilagone CAS#104012-37-5
Tussilagone is a high-purity natural bioactive sesquiterpenoid compound presented as fine white crystalline powder at room temperature. This compound is professionally isolated and purified from natural botanical raw materials, mainly derived from the flower buds ofTussilago farfara belonging to the Asteraceae family, as well as the root tissues of Senecio kleinia Less, featuring pure natural source and stable structural properties.
In terms of solubility characteristics, it exhibits excellent solubility in conventional organic solvents including ether, chloroform, ethyl acetate and methanol, which greatly facilitates laboratory dissolution, sample preparation and pharmacological experimental operation. Nevertheless, the compound is practically insoluble in water, forming distinct solubility differences between organic and aqueous phases.
With stable physical and chemical properties under standard sealed and low-temperature storage conditions, it is widely applicable for natural product identification, bioactivity screening, pharmaceutical mechanism research and related fine chemical research projects, serving as a reliable standard reference substance and experimental raw material for academic and pharmaceutical research fields.
Tussilagone Chemical Properties |
Boiling point | 471.3±35.0 °C(Predicted) |
density | 1.07±0.1 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C |
form | Solid |
color | White to off-white |
InChIKey | CFUPNMDNSQIWBB-UUVDBSHOSA-N |
SMILES | C(O[C@@H]1C[C@@H](C(C)C)[C@@]2([H])[C@]([H])(C1=C)CC(=O)[C@@H]2[C@H](OC(C)=O)C)(=O)/C=C(\C)/CC |
Safety Information |
Safety Statements | 24/25 |
WGK Germany | WGK 3 |
HS Code | 29389090 |
Storage Class | 11 - Combustible Solids |
Product Application of Tussilagone CAS#104012-37-5
Tussilagone is one of the core biologically active ingredients extracted fromTussilago farfara, possessing prominent anti-inflammatory pharmacological properties that support extensive inflammatory mechanism research. It has been verified to effectively alleviate abnormal inflammatory reactions and relieve intestinal tissue damage in dextran sulfate sodium (DSS)-induced murine colitis models, demonstrating significant protective effects against inflammatory bowel injury. In addition, Tussilagone can markedly suppress excessive systemic inflammatory responses and improve the survival rate of experimental animals in cecal ligation and puncture (CLP)-induced sepsis mouse models, revealing great research potential for anti-inflammation and anti-sepsis pharmacological studies[1][2]. This compound is widely used for natural product bioactivity verification, inflammatory mechanism exploration, and pre-clinical pharmaceutical research and development.
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