Diazolidinyl urea (CAS# 78491-02-8)Broad-Spectrum Antimicrobial Preservative for Cosmetics
Reliable Protection, From Production to Final Use
Diazolidinyl Urea is a widely trusted broad-spectrum antimicrobial preservative in the global cosmetics industry. By releasing controlled, low levels of formaldehyde, it creates a durable microbial defense barrier that effectively inhibits bacterial and fungal growth — significantly extending shelf life and ensuring product safety and stability from manufacture through end use.
Diazolidinyl Urea Chemical Properties
| Boiling point | 421.04°C (rough estimate) |
| Density | 1.4734 (rough estimate) |
| Vapor pressure | 0Pa at 20℃ |
| Refractive index | 1.6590 (estimate) |
| Storage temp. | 2-8°C |
| Solubility | Water (Slightly) |
| Form | Solid |
| Pka | 11.22±0.46(Predicted) |
| Color | White to Off-White |
| Water Solubility | 1000g/L at 20℃ |
| Merck | 143,000 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | SOROIESOUPGGFO-UHFFFAOYSA-N |
| LogP | 0.9 at 20℃ |
| CAS DataBase Reference | 78491-02-8(CAS DataBase Reference) |
| EPA Substance Registry System | Diazolidinylurea (78491-02-8) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| WGK Germany | 2 |
| RTECS | YS2717000 |
| HS Code | 29339900 |
| Toxicity | LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen) |
Diazolidinyl Urea is the versatile preservation solution your product line needs. Whether you're formulating leave-on or rinse-off products, it delivers consistent, broad-spectrum protection across your entire portfolio — from creams, lotions, and shampoos to conditioners, liquid cosmetics, and even eye makeup products.
Globally Approved, Commercially Confident
Rest easy knowing your formulations meet the world's most stringent standards. Diazolidinyl Urea is officially approved for use in both the United States and the European Union, giving you the regulatory confidence to launch across major international markets without compromise.
