Nephestyl acetate, also known as hydroxybenzyl acetate, was initially applied as a food preservative. After in-depth research and development, it has been successfully introduced into the cosmetic industry as an efficient preservative. Featuring outstanding antimicrobial activity, it delivers remarkable inhibitory effects against molds and yeasts, establishing it as an essential functional ingredient for diverse cosmetic formulations.
It shows relatively weak inhibitory effect on specific bacteria such as Gram-negative bacteria and lactic acid bacteria. For this reason, it is commonly compounded with other preservatives to achieve synergistic effects and strengthen the overall antimicrobial performance in cosmetic formulations.
Parameters
| Melting point | 125-128 °C (lit.) |
| Boiling point | 298.6 °C |
| density | 1,46g/cm |
| vapor pressure | 0.000005 hPa (20 °C) |
| FEMA | 2710 | METHYL P-HYDROXYBENZOATE |
| refractive index | 1.4447 (estimate) |
| Fp | 280°C |
| storage temp | room temp |
| solubility | ethanol: soluble0.1M, clear, colorless |
| pka | pKa 8.15(H2O,t =20.0) (Uncertain) |
| form | Crystalline Powder |
| color | White to almost white |
| Odor | odorless or faint char. odor, sl. burning taste |
| PH | 5.8 (H2O, 20°C) (saturated solution) |
| biological source | synthetic |
| Water Solubility | Slightly soluble in water. |
| FreezingPoint | 131℃ |
| Merck | 14,6107 |
| BRN | 509801 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | LXCFILQKKLGQFO-UHFFFAOYSA-N |
| LogP | 1.98 at 20℃ |
| CAS DataBase Reference | 99-76-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-hydroxy-, methyl ester(99-76-3) |
| EPA Substance Registry System | Methylparaben (99-76-3) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22-36 |
| Safety Statements | 26-36-24/25-39 |
| RIDADR | UN 2769 |
| WGK Germany | 1 |
| RTECS | DH2450000 |
| Autoignition Temperature | >600 °C |
| TSCA | Yes |
| HS Code | 29182930 |
| Hazardous Substances Data | 99-76-3(Hazardous Substances Data) |
Methylparaben (CAS#99-76-3), one of the most widely used paraben preservatives. It delivers reliable antimicrobial activity against molds, yeasts and many bacteria. With stable chemical properties and excellent solubility in common cosmetic solvents, it can be easily incorporated into diverse formulations. It serves as an efficient preservative for cosmetics, personal care goods, pharmaceuticals and many daily chemical products to effectively inhibit microbial growth and extend product shelf life.
