2-Mercapto-5-methoxybenzimidazole is a versatile heterocyclic fine chemical intermediate widely adopted in pharmaceutical synthesis. It is used in the preparation of COX-2 inhibitors for anti-inflammatory drug development.
It is also employed in the synthesis of multiple high-value benzimidazole derivatives, including 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl] sulfonyl]-1H-benzimidazole, 5-methoxy-2[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide) methyl] sulfonyl]-1H-benzimidazole, as well as tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ²P:P′;1:3κ²P:P′;2:3κ²P:P′-di-μ-bromido-1:2κ⁴Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate for coordination chemistry and catalyst research.
Furthermore, this compound functions as a critical heterocyclic building block for organic synthesis. It is well known as the core intermediate for the drug omeprazole. Omeprazole is a classic anti-ulcer proton pump inhibitor, which can effectively suppress gastric acid secretion. Therefore, 2-Mercapto-5-methoxybenzimidazole is an essential raw material for the manufacture of the anti-ulcer drug Omeprazole.
With stable chemical reactivity and controllable purity, this intermediate is favored by pharmaceutical R&D laboratories and API manufacturers. It supports multi-path organic synthesis and can be applied in custom fine chemical development for new drug discovery.
| 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Chemical Properties |
| Melting point | 261-263 °C(lit.) |
| Boiling point | 309.4±44.0 °C(Predicted) |
| density | 1.2425 (rough estimate) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.5690 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Sparingly) |
| form | Powder |
| pka | 10.13±0.30(Predicted) |
| color | Off-white to light yellow-brown |
| Water Solubility | insoluble |
| Sensitive | Air Sensitive |
| BRN | 3605123 |
| InChI | 1S/C8H8N2OS/c1-11-5-2-3-6-7(4-5)10-8(12)9-6/h2-4H,1H3,(H2,9,10,12) |
| InChIKey | KOFBRZWVWJCLGM-UHFFFAOYSA-N |
| SMILES | COc1ccc2[nH]c(S)nc2c1 |
| LogP | 1.52-2.399 |
| CAS DataBase Reference | 37052-78-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-37-22 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29332900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Skin Sens. 1 |
