Aminophylline CAS#317‑34‑0
Aminophylline is a medicinal compound blended from the bronchodilator theophylline and ethylenediamine at a 2:1 ratio. Acting as a non‑selective adenosine receptor antagonist, histone deacetylase activator and phosphodiesterase inhibitor, it is primarily applied to treat multiple pulmonary disorders such as asthma, COPD, chronic bronchitis and emphysema. Its pharmacological activity in the human body comes from the theophylline fraction. Theophylline works to relax smooth muscles within bronchial passages and pulmonary blood vessels. It competitively blocks type III and type IV phosphodiesterase (PDE), the enzyme responsible for degrading cyclic AMP inside smooth muscle cells, and this mechanism may bring about bronchodilation. Theophylline also attaches to adenosine A2B receptors to counter adenosine‑triggered bronchial narrowing. In addition, under inflammatory conditions, theophylline is capable of activating histone deacetylase, thereby suppressing the transcription of inflammatory genes that rely on histone acetylation to start transcription processes.
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Aminophylline Chemical Properties |
Melting point | 269-270 °C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | H2O: 3.7 mg/mL solutions should be freshly prepared. |
pka | pKa 5.0 (Uncertain) |
form | powder |
color | white to off-white |
Water Solubility | soluble |
Merck | 14,465 |
Cosmetics Ingredients Functions | SKIN CONDITIONING |
InChI | InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2 |
InChIKey | LHRHXWBJUQKYEL-UHFFFAOYSA-N |
SMILES | O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN |
LogP | -0.175 (est) |
CAS DataBase Reference | 317-34-0(CAS DataBase Reference) |
EPA Substance Registry System | 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0) |
Safety Information |
Hazard Codes | Xn,C |
Risk Statements | 22-42/43-34-36/37/38-20/21/22 |
Safety Statements | 45-36/37/39-26-23-36 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | XH5600000 |
F | 10-23 |
TSCA | TSCA listed |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 29339900 |
Hazardous Substances Data | 317-34-0(Hazardous Substances Data) |
Toxicity | LD50 orally in mice: 540 mg/kg (Thompson, Warren) |
Product Application Of Aminophylline CAS#317‑34‑0
Aminophylline features notable vasodilatory and anti‑inflammatory pharmacological properties, and it is occasionally adopted in clinical practice for the therapeutic management of chronic obstructive pulmonary disorder (COPD). In pre‑clinical animal models built for allergen‑triggered pulmonary inflammation, aminophylline can effectively reduce the concentration of inflammatory mediators including IL‑5 and IL‑8, as well as cut down eosinophil counts to ease lung inflammatory responses. This compound is predominantly processed for the formulation of injectable products, and it is widely applied in the production of intravenous injection solutions for relevant pharmaceutical preparations.
Lead Time
‑ Goods from existing inventory: Shipment can be arranged within 2‑3 working days upon receipt of formal order confirmation.
‑ Newly manufactured batches: Production and preparation will take 7‑10 working days before delivery.
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