Methyl acetoacetate, CAS#105-45-3
This product serves as an important fine chemical reagent widely applied in pharmaceutical synthesis. It takes part in the classic Biginelli reaction to construct target molecular structures such as dihydropyrimidinone compounds. Methyl acetoacetate (MAA) is also a key intermediate for manufacturing alpha-substituted acetoacetic esters and a variety of cyclic organic compounds, including pyrazole, pyrimidine and coumarin derivatives. It features active methylene group and excellent reaction activity, enabling it to carry out multiple condensation and cyclization reactions, which makes it highly valuable for lab research and industrial fine chemical production.
Methyl acetoacetate Chemical Properties |
Melting point | -80 °C (lit.) |
Boiling point | 169-170 °C/70 mmHg (lit.) |
density | 1.076 g/mL at 25 °C (lit.) |
vapor density | 4 (vs air) |
vapor pressure | 1 hPa (20 °C) |
refractive index | n20/D 1.419(lit.) |
Fp | 158 °F |
storage temp. | 2-8°C |
solubility | 460 g/L (20°C) |
pka | 10.67±0.46(Predicted) |
form | Liquid |
color | APHA: ≤20 |
Odor | at 100.00 %. fresh fruity citrus green |
PH | 3.8 (863g/l, H2O, 20℃) |
Odor Type | fruity |
explosive limit | 1.3-14.2%(V) |
Water Solubility | 460 g/L (20 ºC) |
Merck | 14,6009 |
BRN | 506727 |
Cosmetics Ingredients Functions | PERFUMING |
InChI | 1S/C5H8O3/c1-4(6)3-5(7)8-2/h3H2,1-2H3 |
InChIKey | WRQNANDWMGAFTP-UHFFFAOYSA-N |
SMILES | COC(=O)CC(C)=O |
LogP | 0.185 (est) |
CAS DataBase Reference | 105-45-3(CAS DataBase Reference) |
NIST Chemistry Reference | Butanoic acid, 3-oxo-, methyl ester(105-45-3) |
EPA Substance Registry System | Methyl acetoacetate (105-45-3) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36 |
Safety Statements | 26 |
RIDADR | NA1993 |
WGK Germany | 1 |
RTECS | AK5775000 |
Autoignition Temperature | 536 °F |
TSCA | TSCA listed |
HazardClass | CBL |
HS Code | 29183000 |
Storage Class | 10 - Combustible liquids |
Hazard Classifications | Eye Dam. 1 |
Hazardous Substances Data | 105-45-3(Hazardous Substances Data) |
Toxicity | LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter) |
Methyl acetoacetate (MAA) CAS#105-45-3
Product Overview
Methyl acetoacetate (MAA, CAS 105-45-3) is a versatile β-keto ester fine chemical intermediate, widely adopted in pharmaceutical synthesis, agrochemical manufacturing, food additive preparation and organic synthesis industries. It is a colorless transparent liquid with a characteristic mild fruity aroma, featuring high reactivity and stable quality under proper storage.
Product Application
Methyl acetoacetate (MAA) has broad industrial application scenarios:
As a chemical reagent for organic synthesis and solvent for cellulose ethers & cellulose resin blends, widely used in coating and polymer formulation.
As a core organic intermediate for pharmaceutical compounds, mainly applied for the synthesis of nifedipine and other cardiovascular APIs.
Used in food additive industry, acting as amine protectant for synthetic sweetener production.
Served as raw material for antibiotic manufacturing and other pharmaceutical fine chemical processes.
Additional application: key intermediate for fungicides, insecticides and herbicides in agrochemical synthesis.
Factory & Production Capability
Our workshop is equipped with continuous synthesis reactors, automatic distillation & rectification systems, online real-time purity monitoring instruments and independent quality control laboratory. The whole production line follows standardized SOP for batch production.
Strict raw material incoming inspection; every batch is sampled and tested before delivery.
Independent QC lab supports full item detection (purity, moisture, acidity, color, non-volatile matter).
Stable monthly output to support both small trial orders and bulk mass supply.
All production processes comply with environmental and safety specifications for fine chemical manufacturing.
After-sales & Technical Service
We provide full set of shipping documents including COA, TDS, MSDS / SDS for each batch free of charge.
Professional chemical technical team supports application consultation, storage guidance and handling instruction.
Quick response for technical inquiries within 24 working hours.
If any quality discrepancy occurs upon receipt, we support batch review and follow-up solution negotiation based on inspection evidence.
Long-term customers can enjoy customized specification trial production and priority delivery arrangement.
Packaging & Transportation
Standard packing: 200kg per galvanized steel drum, export-grade sealed drum with anti-leakage gasket. Custom packing specification available upon request.
Transport classification: UN1993, combustible liquid. Goods are shipped under normal temperature, away from strong oxidants, high heat and open flame.
Container loading: drums are secured and palletized inside container to prevent rolling and leakage during transit.
Logistics: We can support FCA factory or DAP / DDP delivery terms; we will advise proper transport route and precaution tips according to destination country.
Storage suggestion: Store in cool, dry and well-ventilated warehouse, sealed tightly, shelf life 12 months under recommended storage condition.
Customer Cases
We supply MAA to fine chemical manufacturers, pharma intermediate factories and food additive producers across Southeast Asia, Central Asia and Europe.
Long-term cooperation with pharmaceutical intermediate factories for nifedipine synthesis.
Stable supply for agrochemical plants producing fungicide & pesticide intermediates.
Support lab-scale trial orders for R&D institutes and pilot plant testing, then scale up to bulk commercial supply after trial validation.
Our customers praise our stable batch consistency and complete document support for customs clearance.
FAQ
Q1: What is your MOQ?
A: The minimum order quantity is 1 drum (200kg). Bulk order discount is available for large quantity.
Q2: Can you offer custom purity grade?
A: Yes, standard purity ≥99%. Customized specification can be produced after technical confirmation.
Q3: What documents will you provide for customs clearance?
A: Batch COA, TDS, SDS, commercial invoice, packing list, bill of lading / transport document.
Q4: How long is your production & lead time?
A: For standard grade in stock, delivery can be arranged within 3–7 working days. For custom specification, lead time will be confirmed separately.
Q5: Is sample available?
A: Yes, small lab samples are available for quality test; freight cost can be discussed.
Q6: What is the storage requirement for Methyl acetoacetate?
A: Keep sealed in cool, dry, ventilated warehouse, avoid direct sunlight, high temperature and mixing with oxidizing agents.
