4-Chromanone (CAS 491-37-2) is a high-purity, premium bicyclic organic compound widely recognized as a critical fine chemical intermediate in modern organic synthesis and pharmaceutical manufacturing. The product presents as a yellow-brown crystalline solid with stable physical and chemical properties, excellent structural rigidity, and reliable batch-to-batch consistency, making it suitable for laboratory research, pilot-scale trials, and large-scale industrial production.
Featuring a unique fused bicyclic skeleton combined with an active ketone functional group, 4-Chromanone possesses moderate and controllable chemical reactivity. Its stable molecular structure effectively supports various structural modification, derivatization, and cyclization reactions, providing a versatile foundational building block for the synthesis of complex pharmaceutical molecules, bioactive compounds, and high-value specialty chemicals. With a precise molecular weight of 148.16, the compound maintains stable structural performance during conventional synthetic reactions and purification processes.
In terms of solubility characteristics, 4-Chromanone demonstrates excellent solubility in most common organic solvents, including ethanol, methanol, dichloromethane, ethyl acetate, and toluene, while showing nearly insoluble behavior in water. Such favorable solubility properties greatly simplify material feeding, reaction operation, product extraction, and recrystallization procedures, significantly improving overall synthesis efficiency and process stability.
Melting point | 35-38 °C(lit.) |
Boiling point | 127-128 °C13 mm Hg(lit.) |
density | 1.1291 |
refractive index | n20/D 1.575(lit.) |
Fp | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | Crystalline Powder, Crystals or Low Melting Mass |
color | White to yellow |
Water Solubility | Slightly soluble in water. |
BRN | 124652 |
InChIKey | MSTDXOZUKAQDRL-UHFFFAOYSA-N |
LogP | 1.990 (est) |
CAS DataBase Reference | 491-37-2(CAS DataBase Reference) |
NIST Chemistry Reference | 4H-1-Benzopyran-4-one, 2,3-dihydro-(491-37-2) |
EPA Substance Registry System | 4H-1-Benzopyran-4-one, 2,3-dihydro- (491-37-2) |
Hazard Codes | Xi |
Risk Statements | 33-36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 2 |
RTECS | DJ2981225 |
TSCA | Yes |
HazardClass | IRRITANT |
HS Code | 29329990 |
4-Chromanone is a multifunctional fine chemical intermediate for constructing complex organic molecules. It can be derivatized to produce bioactive substances with promising antioxidant and anti-inflammatory effects. Apart from pharmaceutical synthesis, this compound is also widely adopted as a standard substrate for laboratory research on enzyme catalytic performance.
