4-Fluorobenzaldehyde (CAS 459-57-4) is a high-value organic synthetic intermediate. It is normally a colorless to pale yellow liquid with a characteristic aromatic scent. Possessing the typical chemical behavior of aldehydes, it can undergo oxidation, reduction, condensation, and other common organic reactions. The fluorine atom in its molecular structure provides unique reactivity, establishing it as a critical reactive site in numerous synthetic routes.
As a fluorinated analog of benzaldehyde, 4-fluorobenzaldehyde is known to inhibit mushroom tyrosinase. It is used in the preparation of pyrazolopyridine derivatives, which act as mitogen-activated protein kinase (MAPK) inhibitors. Furthermore, it functions as an essential intermediate in the manufacturing of a variety of pharmaceutical ingredients.
| Melting point | -10 °C (lit.) |
| Boiling point | 181 °C/758 mmHg (lit.) |
| density | 1.157 g/mL at 25 °C (lit.) |
| vapor pressure | 19 hPa (70 °C) |
| refractive index | n20/D 1.521(lit.) |
| Fp | 134 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform, Methanol |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.157 |
| Water Solubility | IMMISCIBLE |
| Sensitive | Air Sensitive |
| BRN | 385857 |
| Stability: | Air Sensitive |
| InChIKey | UOQXIWFBQSVDPP-UHFFFAOYSA-N |
| CAS DataBase Reference | 459-57-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzaldehyde, 4-fluoro-(459-57-4) |
| EPA Substance Registry System | Benzaldehyde, 4-fluoro- (459-57-4) |
Safety Information
| Hazard Codes | Xi,F |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39-36/37/39-27 |
| RIDADR | UN 1989 3/PG 3 |
| WGK Germany | 2 |
| F | 9-23 |
| Hazard Note | Flammable |
| TSCA | T |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29130000 |
