1-Ethyl-2-pyrrolidone CAS#2687-91-4

Product Advantages of N-Ethyl-2-pyrrolidone

Powerful Solvent Capacity
This aprotic solvent features powerful dissolving power paired with low volatility and a low dielectric constant, delivering stable dissolving performance for diverse chemical manufacturing workflows.
Efficient Skin Penetration Booster
It works as an outstanding penetration aid. By interacting with the layered lipid structure of the skin’s stratum corneum, it significantly boosts the transdermal absorption efficiency of active ingredients.
Wide Industrial Applicability
Multi-functional for industrial production: it acts as a reliable reaction intermediate for polycarboxylic acid synthesis, and maintains consistent solvent performance under low-light and constant-pressure working environments.
Low Vapor Pressure for Secure Operation
Thanks to its low vapor pressure, evaporation loss and volatile emissions are greatly cut down, creating a safer operating environment for workers.

N-Ethyl-2-pyrrolidone (NEP) is a transparent, colorless low-volatility aprotic solvent with powerful dissolving capacity, low vapor pressure and low dielectric constant.

It delivers notable transdermal penetration promotion performance. It can interact with the layered lipid structure of skin stratum corneum liposomes to facilitate transdermal absorption of active substances.

In industrial production, NEP acts as an excellent general solvent and synthetic intermediate for polycarboxylic acid preparation. It maintains stable performance under low-light and constant-pressure working environments, and participates in formulation systems regulating viscosity and hydrogen bonding.

Safety Reminders

This chemical carries certain toxic risks requiring strict operation management:

Neurotoxicity: May trigger acute solvent poisoning syndrome upon improper exposure.
Hepatotoxicity: Secondary liver toxicant; occupational inhalation or ingestion exposure may induce liver damage, verified by animal toxicology tests.
Reproductive toxicity: Hazardous to reproductive health, likely to hinder reproductive capacity and cause fetal developmental abnormalities in both males and females.

Melting point	87.5-88.5 °C
Boiling point	97 °C/20 mmHg (lit.)
Density	0.992 g/mL at 25 °C (lit.)
Vapor pressure	18Pa at 20℃
Refractive index	n20/D 1.465(lit.)
Fp	169 °F
Storage temp.	Sealed in dry,Room Temperature
Pka	-0.41±0.20(Predicted)
Form	Liquid
Color	Clear
PH	8-9 (100g/l, H2O, 20℃)
Explosive limit	1.3-7.7%(V)
Water Solubility	1000g/L at 23℃
BRN	107971
InChIKey	ZFPGARUNNKGOBB-UHFFFAOYSA-N
LogP	-0.2 at 20℃
CAS DataBase Reference	2687-91-4(CAS DataBase Reference)
NIST Chemistry Reference	1-Ethyl-2-pyrrolidinone(2687-91-4)
EPA Substance Registry System	2-Pyrrolidinone, 1-ethyl- (2687-91-4)