Dimethyl sulfoxide-d6 is a sulfur-containing deuterated compound with the molecular formula (CD₃)₂SO. It is a colorless, nearly odorless transparent liquid at room temperature, featuring a freezing point of 18.45°C and a boiling point of 189°C. It carries a faint bitter taste and possesses excellent miscibility; it can be fully mixed with water, alcohols, ethers and esters in any proportion. Meanwhile, it shows strong hygroscopicity, which means it readily absorbs moisture from ambient air, so sealed storage is mandatory to protect product quality.
DMSO-d6 maintains good chemical stability under 140°C. However, prolonged heating at its boiling point will trigger slow decomposition, generating trace aldehydes, sulfides and mercaptan impurities. Its decomposition rate is significantly accelerated under acidic conditions, while alkaline surroundings can effectively suppress such degradation. For this reason, purification of DMSO-d6 generally adopts vacuum distillation technology. During refining, the system pH value is controlled near 8, or sodium oxalate is added as stabilizer to reduce impurity formation and guarantee high isotopic purity for NMR applications.
As a premium deuterated solvent, DMSO-d6 with high deuteration level is widely used for nuclear magnetic resonance spectroscopy. Its excellent dissolving capacity allows it to dissolve a broad range of organic compounds, pharmaceutical intermediates, natural products and polymer samples that are poorly soluble in other deuterated solvents. An optional grade containing 1% TMS is available for direct chemical shift calibration in NMR testing. Strict quality control is implemented for each batch to ensure low water content and stable isotopic enrichment, delivering consistent, clean spectrum baselines for pharmaceutical R&D and academic laboratory analysis.
Dimethyl sulfoxide-d6 Chemical Properties
Melting point
20.2 °C
Melting point
18,45°C
Boiling point
55 °C5 mm Hg(lit.)
Boiling point
189°C
density
d = 1,19
density
1.190 g/mL at 25 °C(lit.)
vapor pressure
0.42 mm Hg ( 20 °C)
refractive index
n20/D 1.476(lit.)
Fp
185 °F
storage temp.
no restrictions.
solubility
Minimum isotopic purity 99.96%
form
Liquid
color
Colorless
Specific Gravity
1.190
explosive limit
1.8-63%(V)
Water Solubility
Miscible with water and with almost all organic solvents such as alcohols, esters, ketones, chlorinated solvents and aromatic hydrocarbons.
Sensitive
Hygroscopic
BRN
1237248
Stability:
Stable. Combustible. Moisture sensitive. Incompatible with acid chlorides, strong acids, phosphorus halides, strong oxidizing agents, strong reducing agents. Reacts violently with a wide range of materials - consult a full MSDS sheet before starting use.
InChI
1S/C2H6OS/c1-4(2)3/h1-2H3/i1D3,2D3
InChIKey
IAZDPXIOMUYVGZ-WFGJKAKNSA-N
SMILES
[2H]C([2H])([2H])S(=O)C([2H])([2H])[2H]
LogP
-0.69 at 20℃ and pH7
CAS DataBase Reference
2206-27-1(CAS DataBase Reference)
Safety Information
Hazard Codes
Xi
Risk Statements
36/37/38
Safety Statements
26-36-23
RIDADR
NA 1993 / PGIII
WGK Germany
3
RTECS
PV6210000
Autoignition Temperature
573 °F
HS Code
2845 90 10
Storage Class
10 - Combustible liquids
Toxicity
LD50 orally in Rabbit: 14500 mg/kg LD50 dermal Rat 40000 mg/kg
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