Product Application of Potassium bis(trimethylsilyl)amide (KHMDS) CAS#40949-94-8
Potassium bis(trimethylsilyl)amide (KHMDS, typically available as 1M solution in THF) is a high-selectivity non-nucleophilic strong base for advanced organic synthesis. Its outstanding deprotonation performance and low nucleophilic characteristic effectively reduce side reactions in complex synthetic pathways.
The product is utilized in the manufacturing of 5-azacytidine, a well-known antineoplastic drug. It carries out selective deprotonation to build critical structural fragments throughout the API synthesis workflow. Moreover, it participates in the preparation of β3-AR agonists, raw materials applied for anti-stress therapeutic formulations, supporting the construction of core heterocyclic frameworks.
Furthermore, KHMDS is employed to synthesize lanthanide complexes. These metal complexes act as efficient catalysts for various selective cyclization reactions. Apart from the above applications, KHMDS is broadly used for enolate generation, anion formation and organometallic compound preparation in fine chemical research and pharmaceutical intermediate mass production. All operations require anhydrous and oxygen-free environments due to its high sensitivity to moisture.
| Potassium bis(trimethylsilyl)amide Chemical Properties |
| Melting point | 194-195°C |
| Boiling point | 111 °C |
| density | 0.877 g/mL at 25 °C |
| vapor density | 3.2 (vs air) |
| vapor pressure | 54 mm Hg ( 25 °C) |
| refractive index | 1.4920 |
| Fp | 45 °F |
| storage temp. | Refrigerator |
| solubility | Miscible with terahydrofuran, ether, benzene and toluene. |
| form | Liquid |
| color | clear to slightly hazy yellow |
| Specific Gravity | 0.877 |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 4006754 |
| InChI | 1S/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1 |
| InChIKey | IUBQJLUDMLPAGT-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)N([K])[Si](C)(C)C |
| CAS DataBase Reference | 40949-94-8(CAS DataBase Reference) |
| EPA Substance Registry System | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8) |
| Safety Information |
| Hazard Codes | C,F,Xn |
| Risk Statements | 14-34-67-65-63-48/20-11-40-36/37/38-19-37 |
| Safety Statements | 26-36/37/39-45-62-43-46-16-36/37 |
| RIDADR | UN 3263 8/PG 3 |
| WGK Germany | 3 |
| F | 1-3-10 |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29319090 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
