Cordycepin is a naturally occurring adenosine analogue, structurally distinguished by the absence of a hydroxyl group at the 3′ position. Relevant research demonstrates that it can inhibit PARP1 expression and interfere with the polyadenylation process during gene transcription.
This bioactive compound possesses prominent anti-inflammatory properties and delivers valuable neuroprotective effects. It effectively suppresses Aβ-triggered apoptosis, safeguarding the viability of hippocampal neurons. Moreover, cordycepin is verified to induce apoptosis in a broad range of cancer cell lines and exhibits meaningful anti-obesity biological activity.
Beyond that, cordycepin activates the AMPK signalling pathway to delay the progression of cellular senescence. It contributes to preserving stem cell pluripotency and remarkably improves the generation efficiency of induced pluripotent stem (iPS) cells, making it a valuable raw material for regenerative medicine and life science research.
Product Name: | Cordycepin |
Synonyms: | CORDYCEPIN;3’-deoxy-adenosin;9-cordyceposidoadenine;3'-dA;Cordycepin from Cordyceps militaris;Cipargamin;9-(3-deoxypentofuranosyl)-9H-purin-6-amine;3'-Deoxyadenosine(cordycepin) |
CAS: | |
MF: | C10H13N5O3 |
MW: | 251.24 |
EINECS: | 200-791-4 |
Product Categories: | Miscellaneous Natural Products;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;73-03-0 |
Mol File: | 73-03-0.mol |
Melting point | 225-229 °C |
alpha | D20 -47°; D27 -42° |
Boiling point | 394.4°C (rough estimate) |
Density | 1.2938 (rough estimate) |
Refractive index | 1.7610 (estimate) |
Storage temp | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Solubility | Soluble in DMSO (up to 25 mg/ml). |
Rorm | |
Pka | 13?+-.0.60(Predicted) |
Color | White to Off-white |
Biological source | Cordyceps militaris |
λmax | 260nm(EtOH)(lit.) |
Merck | 142529 |
BRN | 35194 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
InChIKey | OFEZSBMBBKLLBJ-BAJZRUMYSA-N |
CAS DataBase Reference | 73-03-0(CAS DataBase Reference) |
EPA Substance Registry System | Adenosine, 3'-deoxy- (73-03-0) |
ordycepin (CAS#73-03-0) is an adenosine analogue characterized by the absence of a hydroxyl group at the 3′ position. It acts as an effective PARP1 inhibitor and is capable of interfering with the polyadenylation process within cells.
This compound displays potent anti-inflammatory activity and exerts neuroprotective effects. It protects hippocampal neurons by alleviating Aβ-triggered apoptotic damage. Additionally, cordycepin can trigger apoptosis in numerous cancer cell lines and presents favourable anti-obesity biological properties.
Moreover, the activation of the AMPK signalling pathway enables cordycepin to slow cellular senescence. It contributes to maintaining stem cell pluripotency and significantly boosts the generation efficiency of induced pluripotent stem (iPS) cells.
